Bioequivalence and Bioavailability Forum

EMA dataset I (PHX/WNL 8.1) [General Statistics]

posted by Helmut – Vienna, Austria, 2020-08-15 17:00 (1519 d 13:20 ago) – Posting: # 21885
Views: 3,523

Hi ElMaestro,

second opinion:

Banded No-Diagonal factor Analytic (f=2)

FA0(2) 10 iterations -2REML LL 504.28342 AIC 526.28342 BIC 566.72771 lambda(1,1) 0.85299473 lambda(1,2) 0.8284068 lambda(2,2) 8.3425233E-07 Var(wR) 0.20211806 Var(wT) 0.11739425 Hypothesis Num_DF Denom_DF F p int 1 74.740719 6165.0288 0 sequence 1 74.725365 0.010773289 0.91761054 treatment 1 207.73496 9.785515 0.0020112901 period 3 192.94942 0.54470318 0.65228368 Diff Diff_SE DF 0.14546428 0.046501237 207.73496 PE 1.1565764 (90% CI: 1.0710441, 1.2489393)

Banded No-Diagonal factor Analytic (f=1)

FA0(1) 6 iterations -2REML LL 504.28342 AIC 524.28342 BIC 561.05095 lambda(1,1) 0.85299474 lambda(1,2) 0.82840679 Var(wR) 0.20211804 Var(wT) 0.11739424 Hypothesis Num_DF Denom_DF F p int 1 74.74072 6165.0288 0 sequence 1 74.725366 0.010773289 0.91761054 treatment 1 207.73498 9.7855157 0.0020112894 period 3 192.94944 0.54470322 0.65228366 Diff Diff_SE DF 0.14546428 0.046501236 207.73498 PE 1.1565764 (90% CI: 1.0710441, 1.2489393)

Heterogenous Compound Symmetry

CSH 8 iterations -2REML LL 504.28342 AIC 526.28282 BIC 566.72712 cshSD(1) 0.85274447 cshSD(2) 0.82831743 cshCorr 1.0005616 Var(wR) 0.20252423 Var(wT) 0.11754154 Hypothesis Num_DF Denom_DF F p int 1 71.172734 6165.1799 0 sequence 1 71.158119 0.010757919 0.91768302 treatment 1 75.532826 9.8154921 0.0024629865 period 3 111.51635 0.54613599 0.65176269 Diff Diff_SE DF 0.14545681 0.046427791 75.532826 PE 1.1565678 (90% CI: 1.0705169, 1.2495357)

A correlation >1 is funny.

Compound Symmetry

CS 4 iterations -2REML LL 504.51200 AIC 504.51200 BIC 561.28753 csDiag -0.00133219 csBlock 0.70154912 Var(wR) 0.20618088 Var(wT) 0.11635790 Hypothesis Num_DF Denom_DF F p int 1 75.415756 6210.7664 0 sequence 1 75.400233 0.010613701 0.91821838 treatment 1 76.346313 9.8473171 0.0024171494 period 3 113.68812 0.54662827 0.65141337 Diff Diff_SE DF 0.14515515 0.046256578 76.346313 PE 1.1562189 (90% CI: 1.0705101, 1.2487890)

Unstructured

UN 4 iterations -2REML LL 504.28282 AIC 526.28282 BIC 566.72712 un(1,1) 0.72717314 un(1,2) 0.70673981 un(2,2) 0.68610978 Var(wR) 0.20252423 Var(wT) 0.11754154 Hypothesis Num_DF Denom_DF F p int 1 74.737874 6165.1798 0 sequence 1 74.722533 0.010757919 0.91766913 treatment 1 75.567795 9.8154921 0.0024626145 period 3 111.56199 0.54613599 0.65176227 Diff Diff_SE DF 0.14545681 0.046427791 75.567795 PE 1.1565678 (90% CI: 1.0705174, 1.2495351)

EMA Method A

-2REML LL 218.14281 AIC 382.14281 BIC 659.29439 Var(w) 0.15999518 Hypothesis Num_DF Denom_DF F p int 1 217 109374.16 0 sequence 1 217 0.24365135 0.62208048 treatment 1 217 9.78364171 0.0020020741 period 3 217 0.78064221 0.50589993 subject(sequence) 75 217 17.844668 0 Diff Diff_SE DF 0.14547367 0.046508691 217 PE 1.1565873 (90% CI: 1.0710567, 1.2489481)

EMA Method B (residual df like SAS DDFM=CONTAIN)

VC 3 iterations -2REML LL 510.34005 AIC 526.34005 BIC 555.75408 Var(w) 0.16010032 Var(b) 0.70693799 Hypothesis Num_DF Denom_DF F p int 1 217 6161.8922 0 sequence 1 217 0.01197525 0.91296138 treatment 1 217 9.8646416 0.0019195216 period 3 217 0.82881025 0.47928487 Diff Diff_SE DF 0.14608818 0.046513007 217 PE 1.1572982 (90% CI: 1.0717074, 1.2497247)

EMA Method B (Satterthwaite’s df)

VC 3 iterations -2REML LL 510.34005 AIC 526.34005 BIC 555.75408 Var(w) 0.16010032 Var(b) 0.70693799 Hypothesis Num_DF Denom_DF F p int 1 74.737599 6161.8922 0 sequence 1 74.720846 0.01197525 0.91315361 treatment 1 216.93862 9.8646416 0.0019195905 period 3 217.11838 0.82881025 0.47928403 Diff Diff_SE DF 0.14608818 0.046513007 216.93862 PE 1.1572982 (90% CI: 1.0717073, 1.2497248)

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Helmut Schütz

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Complete thread:

EMA dataset I, can someone post results? ElMaestro 2020-08-14 20:54 [General Statistics]
- EMA dataset I, can someone post results? PharmCat 2020-08-14 22:09
  - EMA dataset I, can someone post results? ElMaestro 2020-08-14 22:34
- EMA dataset I (PHX/WNL 8.1)Helmut 2020-08-15 15:00
  - EMA dataset I (PHX/WNL 8.1) PharmCat 2020-08-16 00:57
  - EMA dataset I (PHX/WNL 8.1) ElMaestro 2020-08-19 22:50
    - EMA dataset I (PHX/WNL 8.1) Helmut 2020-08-20 01:05

EMA dataset I (PHX/WNL 8.1) [General Sta­tis­tics]

Complete thread:

EMA dataset I (PHX/WNL 8.1) [General Statistics]