long half-life and large variability [Regulatives / Guidelines]

posted by Achievwin – US, 2020-08-12 13:22 (247 d 16:18 ago) – Posting: # 21864
Views: 842

Welcome to the home of funky and funny pharmacokinetics where "Garbage in Gospel out" is day of life.

1. allowing long washout periods have seen studies with 4 -5 months washout.
2. other choice we can imagine is Two stage adaptive study design and including ANCOA in place of ANOVA...

want to know what other experts think?

» In short:
  • pretty long half-life
  • huge total variablity (i.e. within + between variability)
  • total variability is expected to be explained to some degree by some covariates

Complete thread:

Activity
 Admin contact
21,419 posts in 4,475 threads, 1,508 registered users;
online 7 (0 registered, 7 guests [including 2 identified bots]).
Forum time: Saturday 05:40 UTC (Europe/Vienna)

I never did anything worth doing by accident,
nor did any of my inventions come by accident;
they came by work.    Thomas Alva Edison

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5