Open issues [R for BE/BA]

posted by PharmCat  – Russia, 2020-08-07 11:29 (54 d 19:03 ago) – Posting: # 21830
Views: 6,020

Hi ElMaestro!

I thought you asked about p, sorry :)

» Xi is the design matrix for fixed effects for the i'th subject.
» Thus is has a rank of max 3 and never more. This means we can at most use it to work with three parameter estimates. For example an intercept, a treatment effect, a period effect (within any given subject).

I think Xi is not shuld be full-rank design matrix. It is just part of X for subject i. Moreover all Xi should be the same width (num of columns) for Σ(Xi'V-1Xi). Also with (yi - Xi*β) you get residuals ri (col num of Xi should be equal length β).
There is not very accurate description in Gurka's paper, but it provide good concept.
If you check, it should work.

Complete thread:

Activity
 Admin contact
21,090 posts in 4,398 threads, 1,469 registered users;
online 23 (0 registered, 23 guests [including 8 identified bots]).
Forum time: Thursday 06:33 CEST (Europe/Vienna)

In these days, a man who says a thing cannot be done
is quite apt to be interrupted by some idiot doing it.    Elbert Green Hubbard

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5