Not understood [R for BE/BA]

posted by ElMaestro  – Denmark, 2020-08-03 20:55 (258 d 11:24 ago) – Posting: # 21821
Views: 8,163

Hi Pharmcat,


» Do you calculate REML for all data at once or calculate REML subject by subject?

REML is not generally done on a per-subject basis. Each model is assumed to have an optimal fit, given the data and the variance/covariance structure. The optimal fit, when putatively found, corresponds to the fixed effects and the variance components, and the log likelihood serves as objective function.
I am sure I am missing somethign clever in your question. Can you describe what you meant?

» Is it possible to use function caching in R?

You can always write some public members to that effect where necessary and appropriate. I don't think R has a built-in optimizer which takes care of it as the language is interpreted, but other users of this forum should confirm; I am not expert on the inner workings of R.
I do not see how this would affect the REML process - can you describe with more words what your perspective on caching was, then we'll possibly figure out something?

Pass or fail!
ElMaestro

Complete thread:

Activity
 Admin contact
21,419 posts in 4,475 threads, 1,510 registered users;
online 12 (1 registered, 11 guests [including 5 identified bots]).
Forum time: Monday 08:20 UTC (Europe/Vienna)

There is one certainty in drug development
and statistics that one can depend on:
the data are always late.    Scott Patterson and Byron Jones

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5