Pre-clinical PK/PD Parameters [PK / PD]

posted by VijithRoy – India, 2020-07-31 08:18 (14 d 20:04 ago) – Posting: # 21812
Views: 710

Dear Dshah,
Thank you for you valuable reply,

» The three pharmacodyamic properties of antibiotics that best describe killing activity are time-dependence, concentration-dependence, and persistent effects. The rate of killing is determined by either the length of time necessary to kill (time-dependent), or the effect of increasing concentrations (concentration-dependent). Persistent effects include the Post-Antibiotic Effect (PAE). PAE is the persistant suppression of bacterial growth following antibiotic exposure.

Consider a new antimicrobial drug, to determine their killing activity (Which would be anyone one of the 3 parameter)., We have to undergo all the 3 invitro PD parameter(PeaK/MIC, Time/MIC, 24AUC/MIC ) and determine which parameter the drug best suits ??

Complete thread:

Activity
 Admin contact
21,026 posts in 4,382 threads, 1,460 registered users;
online 8 (0 registered, 8 guests [including 5 identified bots]).
Forum time: Saturday 04:23 CEST (Europe/Vienna)

It has yet to be proven
that intelligence has any survival value.    Arthur C. Clarke

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5