Pre-clinical PK/PD Parameters [PK / PD]

posted by VijithRoy – India, 2020-07-31 10:18 (921 d 07:12 ago) – Posting: # 21812
Views: 3,775

Dear Dshah,
Thank you for you valuable reply,

❝ The three pharmacodyamic properties of antibiotics that best describe killing activity are time-dependence, concentration-dependence, and persistent effects. The rate of killing is determined by either the length of time necessary to kill (time-dependent), or the effect of increasing concentrations (concentration-dependent). Persistent effects include the Post-Antibiotic Effect (PAE). PAE is the persistant suppression of bacterial growth following antibiotic exposure.


Consider a new antimicrobial drug, to determine their killing activity (Which would be anyone one of the 3 parameter)., We have to undergo all the 3 invitro PD parameter(PeaK/MIC, Time/MIC, 24AUC/MIC ) and determine which parameter the drug best suits ??

With Best Regards,
Vroy.

Complete thread:

UA Flag
Activity
 Admin contact
22,485 posts in 4,710 threads, 1,603 registered users;
20 visitors (0 registered, 20 guests [including 9 identified bots]).
Forum time: 16:31 CET (Europe/Vienna)

The difference between a surrogate and a true endpoint
is like the difference between a cheque and cash.
You can get the cheque earlier but then,
of course, it might bounce.    Stephen Senn

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5