Pre-clinical PK/PD Parameters [PK / PD]

posted by VijithRoy – India, 2020-07-31 08:18 (170 d 06:55 ago) – Posting: # 21812
Views: 1,372

Dear Dshah,
Thank you for you valuable reply,

» The three pharmacodyamic properties of antibiotics that best describe killing activity are time-dependence, concentration-dependence, and persistent effects. The rate of killing is determined by either the length of time necessary to kill (time-dependent), or the effect of increasing concentrations (concentration-dependent). Persistent effects include the Post-Antibiotic Effect (PAE). PAE is the persistant suppression of bacterial growth following antibiotic exposure.

Consider a new antimicrobial drug, to determine their killing activity (Which would be anyone one of the 3 parameter)., We have to undergo all the 3 invitro PD parameter(PeaK/MIC, Time/MIC, 24AUC/MIC ) and determine which parameter the drug best suits ??

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