Good luck :-) [PK / PD]

posted by VijithRoy – India, 2020-07-29 13:51 (263 d 11:35 ago) – Posting: # 21797
Views: 1,605

» Please follow up and post about your experience once the study is done, there are so many unexpected little practical surprises in these studies. Few CROs specialise in this area.

Once again, Hello !!

Successfully done one clamp study for insulin drug for 24 hour under fasting state on healthy subject.

Really it was so interesting on every 5mins & 10mins blood collection, how team co-ordination works and also the study is mostly depend upon machine based algorithms (YSI Glucose analyser & software to calculate & output the clamp values), i found the clamp value was changing over each ysi glucose analyser though it is calibrated every 2hours.

Man power is most needed to assist proper maintaining the clamp procedure.

The nurse and phlebotomist has the major pressure on them, since they are in the blood collection and subject monitoring process.

Though i spent whole 24hrs in the study, i miss the rationale behind the study.
which drugs need this glucose clamp study ?

Respect your reply !!

Thank you.


Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5[Helmut]

With Best Regards,
Vroy.

Complete thread:

Activity
 Admin contact
21,419 posts in 4,475 threads, 1,509 registered users;
online 13 (0 registered, 13 guests [including 3 identified bots]).
Forum time: Monday 01:27 CEST (Europe/Vienna)

There is one certainty in drug development
and statistics that one can depend on:
the data are always late.    Scott Patterson and Byron Jones

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5