Bioequivalence and Bioavailability Forum • And by the way....

And by the way.... [R for BE/BA]

posted by ElMaestro – Belgium?, 2020-07-24 12:52 (19 d 16:12 ago) – Posting: # 21785
Views: 2,750

Obj.F12=function(Pars)

##returns the restricted log likelihood.

##apart from k, this is line 3 of page 10 of:

##http://people.csail.mit.edu/xiuming/docs/tutorials/reml.pdf

##k is defined from the number of observations, and .

{

  CovM=Create.CovM(Pars)

  k=  -((length(y)-ncol(X))/2)*log(2*pi)

  A= -0.5*log( det(CovM)) 

  B= -0.5*log( det(t(X) %*% solve(CovM) %*% X)) 

  est.b = solve(t(X) %*% solve(CovM) %*% X) %*% t(X) %*% solve(CovM) %*% y

  tmp= y - X %*% est.b

  C=-0.5 *(t(tmp) %*% solve(CovM) %*% tmp)

  return(k+A+B+C)

}

....this is exactly also the REML likelihood function that SAS defines.

—
I could be wrong, but...

Best regards,
ElMaestro

"Pass or fail" (D. Potvin et al., 2008)

Complete thread:

Semireplicated + REML in R ElMaestro 2020-07-10 13:19 [R for BE/BA]
- Semireplicated + REML in R Helmut 2020-07-10 19:03
  - Semireplicated + REML in R ElMaestro 2020-07-10 19:24
    - Avoid partial replicate designs, pleeeze! Helmut 2020-07-11 11:57
      - Avoid partial replicate designs, pleeeze! ElMaestro 2020-07-11 14:43
        
        Braveheart! Helmut 2020-07-11 15:38
        
        Who can help? ElMaestro 2020-07-12 12:28
        
        Who can help? ElMaestro 2020-07-12 13:26
        Update II ElMaestro 2020-07-12 21:36
        
        Update III ElMaestro 2020-07-12 21:46
        
        Final update today ElMaestro 2020-07-12 22:27
        
        Medium rare. Helmut 2020-07-13 13:52
        
        took just 52 hrs to do it :-) ElMaestro 2020-07-13 14:18
        
        Will take much more hours still… Helmut 2020-07-13 15:34
        
        Negative determinant ElMaestro 2020-07-14 03:22
        
        Are we loosers? Helmut 2020-07-14 13:58
        
        "we"? Loosers? ElMaestro 2020-07-14 15:07
        
        Misunderstanding? Helmut 2020-07-14 15:32
        
        Braveheart! ElMaestro 2020-07-13 10:13
        
        Braveheart! Helmut 2020-07-13 14:16
        Braveheart! PharmCat 2020-07-15 14:19
        
        Braveheart! ElMaestro 2020-08-02 17:39
- We were all blind (except Detlew) Helmut 2020-07-15 14:27
  - It is the opposite way around for me ElMaestro 2020-07-15 16:25
    - Desultory thoughts Helmut 2020-07-15 17:33
      - FDA RSABE is ISC d_labes 2020-07-15 18:13
        
        FDA RSABE is ISC Helmut 2020-07-16 11:11
      - Desultory thoughts ElMaestro 2020-07-15 23:06
        
        Desultory thoughts Helmut 2020-07-16 10:59
  - Phoenix - which template? mittyri 2020-07-19 00:42
    - FDA RSABE Project template_ v1.4.phxproj Helmut 2020-07-19 01:45
- "By popular demand": likelihood ElMaestro 2020-07-24 10:07
  - And by the way....ElMaestro 2020-07-24 12:52
    - And by the way.... PharmCat 2020-08-03 14:24
      - Not understood ElMaestro 2020-08-03 22:55
        
        Not understood PharmCat 2020-08-05 01:41
        
        Not understood ElMaestro 2020-08-05 08:13
        
        Not understood PharmCat 2020-08-05 16:37
        
        Open issues ElMaestro 2020-08-06 21:11
        
        Open issues PharmCat 2020-08-07 00:02
        
        Open issues ElMaestro 2020-08-07 07:49
        
        Open issues PharmCat 2020-08-07 11:29
        
        Still can't make it work ElMaestro 2020-08-07 13:08
        
        Still can't make it work PharmCat 2020-08-07 15:42
        
        Still can't make it work ElMaestro 2020-08-07 16:44
        
        Still can't make it work PharmCat 2020-08-07 18:14
        
        Still can't make it work ElMaestro 2020-08-07 18:23
        
        And now it works ElMaestro 2020-08-07 21:31
        Still can't make it work PharmCat 2020-08-08 01:08
        
        Speed improvement ElMaestro 2020-08-08 12:25
        
        Speed improvement PharmCat 2020-08-08 17:27
        Speed improvement ElMaestro 2020-08-08 18:10
        
        Speed improvement PharmCat 2020-08-09 18:22
        Some tests... PharmCat 2020-08-10 11:48