Pre-clinical PK/PD Parameters [PK / PD]

posted by VijithRoy – India, 2020-07-22 09:34 (930 d 07:32 ago) – Posting: # 21770
Views: 4,487

Hello all,

When i was going through the PK parameters of an antibacterial drug, i got stuck up at one point with the background concept behind.

So basically, the three parameters are, Concentration/MIC, Time>MIC, AUC/MIC - These are the Gold standard for evaluating Antibiotic PK-PD & Dosage regimen.

My question is,
1. How the drugs(Antibiotics) are classified under one of these parameters ?
E.g - Aminoglycoside - it comes under Concentration dependent killing (i.e, Conc/MIC).
why can't this come under time/MIC ?? :confused:


Please kindly help me out.

Thanks in Advance !!

With Best Regards,
Vroy.

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