Glucose Clamp Study [PK / PD]

posted by VijithRoy – India, 2020-07-22 04:11 (704 d 02:45 ago) – Posting: # 21769
Views: 2,611

Dear ElMaestro !!

Thank you so much :-)
i got your point and here in my working place (BABE Unit), clamp study is going to conduct in up coming weeks. the study goes like this,

Subjects will be housed (Day 0), that so to ensure 10hr fasting before pre-dose.

On day of dosing, One hand will be cannulated for blood collection and other hand for Continous IV 20% Dextrose solution will be infused.

Once the subject gets stable, pre dose samples are taken and clamp value is measured (Mean glucose level). Then T/R 0.4IU/Kg will be administered SC. Blood sampling 0.3ml for every 5mins for 12hrs & 0.5ml for evry 1omins for 12-24hr.

Then with 20% dextrose adjusted.

this is how current rough procedure study goes out here.


Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5[Helmut]

With Best Regards,
Vroy.

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