Bioequivalence and Bioavailability Forum

Hello VijithRoy,

❝ Under Clamp technique, Only insulin like drugs can be tested ?

No, in principle any situation when you wish to keep glucose levels up and safe you can do a clamp.
I recall in India how subjects were drinking glucose water before taking a dose of metformin in a BE trial on hevo's. In such a situation a clamp might have achieved the same. The example is not very good, of course, because it is easier to drink glucose than to do start a clamp, but I hope you get the idea.
(metformin: hevo's were puking when drinking the sweet stuff at 7:53AM, and when one subject pukes, 17 others will follow, so these studies with oral glucose solution had a lot of discontinuations and AEs and stuff; why the f%ck not just try and standardise intake of something sweet which is liked by volunteers: Halwa, Gulab Jamun, ice cream, but no.... glucose solution dictated by DCGI/CDSCO/ethics... that's beyond me.... I am sure there are good arguments, I just don't know of them or will not recognise them as better than a lot of other alternatives )