Reanalysis for PK Reason: Gone with the Wind [Bioanalytics]

posted by Obinoscopy  – USA, 2020-07-20 14:12 (379 d 11:54 ago) – Posting: # 21761
Views: 2,865

Hi Dshah

» time concentration 1 concentration 2 concentration 3 concentration 4
» AUC      826.125         826.375         826.625         826.75

» I believe that such small change in AUC can be considered non-significant. :-)

I agree with you that these changes are very little. But you'd be amazed at how the difference between 826.125 and 826.375 is enough to make a study that failed (eg CI of T/R: 79.99 - 111.11) to pass (eg CI of T/R: 80.02 - 111.11).

Regards,

Scopy

Complete thread:

Activity
 Admin contact
21,606 posts in 4,517 threads, 1,532 registered users;
online 6 (0 registered, 6 guests [including 3 identified bots]).
Forum time: Wednesday 02:06 CEST (Europe/Vienna)

Scientists cannot simply hang their subjectivities
up on a hook outside the laboratory door.    Ruth Bleier

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5