Reanalysis for PK Reason: Gone with the Wind [Bioanalytics]

posted by Obinoscopy  – USA, 2020-07-20 12:12 (99 d 22:41 ago) – Posting: # 21761
Views: 1,846

Hi Dshah

» time concentration 1 concentration 2 concentration 3 concentration 4
» AUC      826.125         826.375         826.625         826.75

» I believe that such small change in AUC can be considered non-significant. :-)

I agree with you that these changes are very little. But you'd be amazed at how the difference between 826.125 and 826.375 is enough to make a study that failed (eg CI of T/R: 79.99 - 111.11) to pass (eg CI of T/R: 80.02 - 111.11).

Regards,

Scopy

Complete thread:

Activity
 Admin contact
21,179 posts in 4,414 threads, 1,474 registered users;
online 5 (0 registered, 5 guests [including 4 identified bots]).
Forum time: Wednesday 10:53 UTC (Europe/Vienna)

Actually, science starts to become interesting
only where it ends.    Justus von Liebig

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5