Reanalysis for PK Reason: Gone with the Wind [Bioanalytics]

posted by Obinoscopy  – USA, 2020-07-20 14:12 (20 d 22:53 ago) – Posting: # 21761
Views: 1,352

Hi Dshah

» time concentration 1 concentration 2 concentration 3 concentration 4
» AUC      826.125         826.375         826.625         826.75

» I believe that such small change in AUC can be considered non-significant. :-)

I agree with you that these changes are very little. But you'd be amazed at how the difference between 826.125 and 826.375 is enough to make a study that failed (eg CI of T/R: 79.99 - 111.11) to pass (eg CI of T/R: 80.02 - 111.11).

Regards,

Scopy

Complete thread:

Activity
 Admin contact
20,992 posts in 4,375 threads, 1,460 registered users;
online 17 (0 registered, 17 guests [including 8 identified bots]).
Forum time: Monday 13:05 CEST (Europe/Vienna)

[Those] who have an excessive faith in their theories or in their
ideas are not only poorly disposed to make discoveries, but they
also make very poor observations.    Claude Bernard

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5