## Reanalysis for PK Reason: Gone with the Wind [Bioanalytics]

Hi Dshah

time concentration 1 concentration 2 concentration 3 concentration 4

❝ AUC      826.125         826.375         826.625         826.75

❝ I believe that such small change in AUC can be considered non-significant.

I agree with you that these changes are very little. But you'd be amazed at how the difference between 826.125 and 826.375 is enough to make a study that failed (eg CI of T/R: 79.99 - 111.11) to pass (eg CI of T/R: 80.02 - 111.11).

Regards,

Scopy