3-period full replicates [Design Issues]

posted by Helmut Homepage – Vienna, Austria, 2020-07-20 10:04 (757 d 05:08 ago) – Posting: # 21757
Views: 1,521

Hi Loky do,

» I think some countries like ours are very traditional in following guidelines,…

Agree. But the Egyptian GL of 2017 in Section 3.2 recommends the EMA’s approach and not the FDA’s. That’s not a different league but a different sport. For the SAS-codes recommended by the EMA see the Q&A document. Alternatively* you can use Phoenix/WinNonlin, STATISTICA, SPSS, Stata, JPM, or the [image]-pack­age replicateBE.

» why using partially replicate design is not favorable nowadays? :confused:

As a starter see this post and that one. I suggest also to search the forum with the keywords lousy and design. Most important reasons:

Dif-tor heh smusma 🖖 [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
22,302 posts in 4,667 threads, 1,585 registered users;
online 9 (0 registered, 9 guests [including 3 identified bots]).
Forum time: Tuesday 15:13 CEST (Europe/Vienna)

In matters of style, swim with the current;
in matters of principle, stand like a rock.    Thomas Jefferson

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5