Bioequivalence and Bioavailability Forum

PK modeling in BE [NCA / SHAM]

posted by mittyri – Russia, 2020-07-19 00:24 (756 d 02:24 ago) – Posting: # 21744
Views: 2,583

Hi Helmut,

» However, last year at the 10^th American Conference on Pharmacometrics (20–23 October, Orlando) she gave a presentation “Evaluation of Model Based BioEquivalence (MBBE) statistical approaches for sparse designs PK studies” with a whoopy mean (!) Type I Error of 7.6%. 

Are you referring to this one?
Stan approach is a bit better, but still questionable

Complete thread:

• Truncated 72 hours mmw 2015-02-09 11:12 [NCA / SHAM] 
  • Truncated 72 hours Dr_Dan 2015-02-09 12:59
  • Truncated 72 hours Helmut 2015-02-09 16:10
    • Truncated 72 hours nobody 2015-02-09 22:48
      • Truncated 72 hours mmw 2015-02-11 12:57
    • Truncated 72 hours stic-stats 2020-07-13 14:22
      • Truncated 72 hours Helmut 2020-07-13 17:07
        • Truncated 72 hours stic-stats 2020-07-15 06:17
    • Truncated 72 hours M.tareq 2020-07-16 01:36
      • Truncated 72 hours Helmut 2020-07-16 11:56
        • Truncated 72 hours M.tareq 2020-07-16 17:05
          • PK modeling in BE Helmut 2020-07-16 18:30
            • PK modeling in BEmittyri 2020-07-19 00:24
              • PK modeling in BE Helmut 2020-07-19 12:35