Bioequivalence and Bioavailability Forum

Desultory thoughts [🇷 for BE/BA]

posted by Helmut  – Vienna, Austria, 2020-07-16 12:59 (1609 d 23:23 ago) – Posting: # 21708
Views: 23,359

Hi ElMaestro,

❝ May I offer the completely opposite view? Search the forum for "bogus statement" , check the SAS documentation for what the statement actually actually does to Proc GLM: […]

I know, I know.
I was talking about a mixed model and not the way how SAS uses the RANDOM statement in PROC GLM in order to get the DFs right.
A true all fixed effects model – with subjects instead of the crazy subjects(sequence) – requires unique coding of subjcts. In practice always the case (OK, maybe not in multi-center studies but then you have center as another fixed effect). I recently reviewed a manuscript where subjects in each sequence had the same codes. The authors obviously had no clue about how things work.

BTW, same agencies require that in crossovers CV_intra and CV_inter are reported. The latter is not possible when subject is a fixed effect.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

• Semireplicated + REML in R ElMaestro 2020-07-10 13:19 [🇷 for BE/BA] 
  • Semireplicated + REML in R Helmut 2020-07-10 19:03
    • Semireplicated + REML in R ElMaestro 2020-07-10 19:24
      • Avoid partial replicate designs, pleeeze! Helmut 2020-07-11 11:57
        • Avoid partial replicate designs, pleeeze! ElMaestro 2020-07-11 14:43
          • Braveheart! Helmut 2020-07-11 15:38
            • Who can help? ElMaestro 2020-07-12 12:28
              • Who can help? ElMaestro 2020-07-12 13:26
              • Update II ElMaestro 2020-07-12 21:36
                • Update III ElMaestro 2020-07-12 21:46
              • Final update today ElMaestro 2020-07-12 22:27
                • Medium rare. Helmut 2020-07-13 13:52
                  • took just 52 hrs to do it :-) ElMaestro 2020-07-13 14:18
                    • Will take much more hours still… Helmut 2020-07-13 15:34
                  • Negative determinant ElMaestro 2020-07-14 03:22
                    • Are we loosers? Helmut 2020-07-14 13:58
                      • "we"? Loosers? ElMaestro 2020-07-14 15:07
                        • Misunderstanding? Helmut 2020-07-14 15:32
            • Braveheart! ElMaestro 2020-07-13 10:13
              • Braveheart! Helmut 2020-07-13 14:16
              • Braveheart! PharmCat 2020-07-15 14:19
                • Braveheart! ElMaestro 2020-08-02 17:39
  • We were all blind (except Detlew) Helmut 2020-07-15 14:27
    • It is the opposite way around for me ElMaestro 2020-07-15 16:25
      • Desultory thoughts Helmut 2020-07-15 17:33
        • FDA RSABE is ISC d_labes 2020-07-15 18:13
          • FDA RSABE is ISC Helmut 2020-07-16 11:11
        • Desultory thoughts ElMaestro 2020-07-15 23:06
          • Desultory thoughtsHelmut 2020-07-16 10:59
    • Phoenix - which template? mittyri 2020-07-19 00:42
      • FDA RSABE Project template_ v1.4.phxproj Helmut 2020-07-19 01:45
  • "By popular demand": likelihood ElMaestro 2020-07-24 10:07
    • And by the way.... ElMaestro 2020-07-24 12:52
      • And by the way.... PharmCat 2020-08-03 14:24
        • Not understood ElMaestro 2020-08-03 22:55
          • Not understood PharmCat 2020-08-05 01:41
            • Not understood ElMaestro 2020-08-05 08:13
              • Not understood PharmCat 2020-08-05 16:37
                • Open issues ElMaestro 2020-08-06 21:11
                  • Open issues PharmCat 2020-08-07 00:02
                    • Open issues ElMaestro 2020-08-07 07:49
                      • Open issues PharmCat 2020-08-07 11:29
                        • Still can't make it work ElMaestro 2020-08-07 13:08
                          • Still can't make it work PharmCat 2020-08-07 15:42
                            • Still can't make it work ElMaestro 2020-08-07 16:44
                              • Still can't make it work PharmCat 2020-08-07 18:14
                                • Still can't make it work ElMaestro 2020-08-07 18:23
                                  • And now it works ElMaestro 2020-08-07 21:31
                                  • Still can't make it work PharmCat 2020-08-08 01:08
                                    • Speed improvement ElMaestro 2020-08-08 12:25
                                      • Speed improvement PharmCat 2020-08-08 17:27
                                      • Speed improvement ElMaestro 2020-08-08 18:10
                                        • Speed improvement PharmCat 2020-08-09 18:22
                                        • Some tests... PharmCat 2020-08-10 11:48