Truncated 72 hours [NCA / SHAM]

posted by M.tareq  – 2020-07-15 23:36 (30 d 01:49 ago) – Posting: # 21706
Views: 975

» In my protocols I state to use an estimated value anyway. This not only helps to correct for deviations from scheduled sampling times, but with ‘missings’ as well.

Is it possible to use a model-based approach to estimate the overall/typical value of Ke or CL and use that for prediction of such points ?

Or is it simpler to just perform a log-linear regression on averaged/all terminal points (3xTmax) and use that estimate to account for such deviations as defined in protocol.



Complete thread:

 Admin contact
21,026 posts in 4,382 threads, 1,460 registered users;
online 6 (0 registered, 6 guests [including 3 identified bots]).
Forum time: Saturday 01:25 UTC (Europe/Vienna)

It has yet to be proven
that intelligence has any survival value.    Arthur C. Clarke

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz