Truncated 72 hours [NCA / SHAM]

posted by M.tareq  – 2020-07-16 01:36 (96 d 06:04 ago) – Posting: # 21706
Views: 1,333

» In my protocols I state to use an estimated value anyway. This not only helps to correct for deviations from scheduled sampling times, but with ‘missings’ as well.

Is it possible to use a model-based approach to estimate the overall/typical value of Ke or CL and use that for prediction of such points ?

Or is it simpler to just perform a log-linear regression on averaged/all terminal points (3xTmax) and use that estimate to account for such deviations as defined in protocol.

Thanks

Mahmoud

Complete thread:

Activity
 Admin contact
21,164 posts in 4,410 threads, 1,476 registered users;
online 3 (0 registered, 3 guests [including 2 identified bots]).
Forum time: Tuesday 07:40 CEST (Europe/Vienna)

In theory, there is no difference between theory and practice.
But, in practice, there is.    Jan L.A. van de Snepscheut

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5