Truncated 72 hours [NCA / SHAM]

posted by M.tareq  – 2020-07-16 01:36 (299 d 07:26 ago) – Posting: # 21706
Views: 1,918

» In my protocols I state to use an estimated value anyway. This not only helps to correct for deviations from scheduled sampling times, but with ‘missings’ as well.

Is it possible to use a model-based approach to estimate the overall/typical value of Ke or CL and use that for prediction of such points ?

Or is it simpler to just perform a log-linear regression on averaged/all terminal points (3xTmax) and use that estimate to account for such deviations as defined in protocol.

Thanks

Mahmoud

Complete thread:

Activity
 Admin contact
21,446 posts in 4,483 threads, 1,511 registered users;
online 17 (0 registered, 17 guests [including 14 identified bots]).
Forum time: Tuesday 09:03 CEST (Europe/Vienna)

The fact that some geniuses were laughed at
does not imply that all who are laughed at are geniuses.    Carl Sagan

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5