Sample Size determination for comparability studies [Power / Sample Size]
Hi sedhosen,
What do you mean by “comparability”? The most common ones:
Not at all. Since the difference between treatments and its variability are assumptions, you can only estimate the sample size.
❝ Is there any guideline (or even an article) for determining sample size in comparability studies?
What do you mean by “comparability”? The most common ones:
- Testing for equivalence. This is a two-sided test, generally performed at a nominal level α 0.05.
- Testing for non-inferioriy (e.g., verum vs. placebo, where you assume that higher responses are better). This is a one-sided test, generally performed at a nominal level α 0.025.
- Testing for non-superiority (e.g., in safety studies comparing a new treatment to an established one and you assume that lower responses are better). A one-sided test as well.
❝ How should we calculate it?
Not at all. Since the difference between treatments and its variability are assumptions, you can only estimate the sample size.
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Sample Size determination for comparability studies sedhosen 2020-07-14 15:10 [Power / Sample Size]
- Sample Size determination for comparability studiesHelmut 2020-07-14 15:50
- Sample Size determination for comparability studies sedhosen 2020-07-19 16:13
- Sample Size determination for comparability studiesHelmut 2020-07-14 15:50