Bioequivalence and Bioavailability Forum • Truncated 72 hours

Truncated 72 hours [NCA / SHAM]

posted by stic-stats – India, 2020-07-13 16:22 (988 d 00:12 ago) – Posting: # 21687
Views: 3,331

Dear Helmut and All,

❝ ❝ But it was found that around one-third of the study population did not turn up for 72.00 hours ambulatory sample.

❝

❝ Shit happens. Since AUC₇₂ is a primary PK metric consider hospitalizing subjects in the future. By opting for ambulatory sampling you saved some rupees but risked to substantially loose power.

May I know what type of power loose.
please clarify my dought.

Is their any impact on calculation of AUC due to number of missed sample? Could these subjects be excluded from statistical analysis? If yes, on what basis we exclude these subjects?

Regards,
Stic-Stats.

Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5. Standard quotes restored; see also this post #8. [Helmut]

Complete thread:

Truncated 72 hours mmw 2015-02-09 11:12 [NCA / SHAM]
- Truncated 72 hours Dr_Dan 2015-02-09 12:59
- Truncated 72 hours Helmut 2015-02-09 16:10
  - Truncated 72 hours nobody 2015-02-09 22:48
    - Truncated 72 hours mmw 2015-02-11 12:57
  - Truncated 72 hoursstic-stats 2020-07-13 14:22
    - Truncated 72 hours Helmut 2020-07-13 17:07
      - Truncated 72 hours stic-stats 2020-07-15 06:17
  - Truncated 72 hours M.tareq 2020-07-16 01:36
    - Truncated 72 hours Helmut 2020-07-16 11:56
      - Truncated 72 hours M.tareq 2020-07-16 17:05
        
        PK modeling in BE Helmut 2020-07-16 18:30
        
        PK modeling in BE mittyri 2020-07-19 00:24
        
        PK modeling in BE Helmut 2020-07-19 12:35