Truncated 72 hours [NCA / SHAM]

posted by stic-stats – India, 2020-07-13 14:22 (27 d 23:54 ago) – Posting: # 21687
Views: 1,082

Dear Helmut and All,

» » But it was found that around one-third of the study population did not turn up for 72.00 hours ambulatory sample.
» Shit happens. Since AUC72 is a primary PK metric consider hospitalizing subjects in the future. By opting for ambulatory sampling you saved some rupees but risked to substantially loose power.

May I know what type of power loose.
please clarify my dought.

Is their any impact on calculation of AUC due to number of missed sample? Could these subjects be excluded from statistical analysis? If yes, on what basis we exclude these subjects?


Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5. Standard quotes restored; see also this post #8[Helmut]

Complete thread:

 Admin contact
20,993 posts in 4,376 threads, 1,460 registered users;
online 28 (1 registered, 27 guests [including 13 identified bots]).
Forum time: Monday 14:16 CEST (Europe/Vienna)

[Those] who have an excessive faith in their theories or in their
ideas are not only poorly disposed to make discoveries, but they
also make very poor observations.    Claude Bernard

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz