Truncated 72 hours [NCA / SHAM]

posted by stic-stats – India, 2020-07-13 14:22 (279 d 12:28 ago) – Posting: # 21687
Views: 1,981

Dear Helmut and All,

» » But it was found that around one-third of the study population did not turn up for 72.00 hours ambulatory sample.
»
» Shit happens. Since AUC72 is a primary PK metric consider hospitalizing subjects in the future. By opting for ambulatory sampling you saved some rupees but risked to substantially loose power.

May I know what type of power loose.
please clarify my dought.

Is their any impact on calculation of AUC due to number of missed sample? Could these subjects be excluded from statistical analysis? If yes, on what basis we exclude these subjects?

Regards,
Stic-Stats.


Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5. Standard quotes restored; see also this post #8[Helmut]

Complete thread:

Activity
 Admin contact
21,419 posts in 4,475 threads, 1,509 registered users;
online 8 (0 registered, 8 guests [including 3 identified bots]).
Forum time: Monday 02:50 CEST (Europe/Vienna)

There is one certainty in drug development
and statistics that one can depend on:
the data are always late.    Scott Patterson and Byron Jones

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5