Braveheart! [R for BE/BA]

posted by Helmut Homepage – Vienna, Austria, 2020-07-11 15:38 (32 d 13:49 ago) – Posting: # 21674
Views: 5,047

Hi ElMaestro,

» it is rather experimental.

:-D

» […] which means we have:
» A variance for T (combined within and between)
» A variance for within-R
» A variance for between-R

Correct. Will be interesting what you get because \(\sigma_{wT}^2+\sigma_{bT}^2\):
0.04367 (Phoenix) and 0.03771 (SAS).

» Hessian, positive definite, etc.. [image]all this comes down to the details of SAS's or WinNonlin's optimiser. I am playing around with optim in R (BFGS, L-BFGS-B bounded, and Nelder-Mead) and with one of my own making.

If you succeed, the community will love you. Might win you the Fields medal.

As long as a genius (you?) is not able to come up with a solution working in all cases, I can only repeat:

Avoid partial replicate designs!

It might not be possible to evaluate the study for ABE (though RSABE works in any case).

Dif-tor heh smusma 🖖
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Activity
 Admin contact
21,009 posts in 4,379 threads, 1,460 registered users;
online 10 (0 registered, 10 guests [including 7 identified bots]).
Forum time: Thursday 05:28 CEST (Europe/Vienna)

If you obey all the rules,
you will miss all the fun.    Katharine Hepburn

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5