Braveheart! [🇷 for BE/BA]

posted by Helmut Homepage – Vienna, Austria, 2020-07-11 17:38 (2165 d 22:41 ago) – Posting: # 21674
Views: 40,391

Hi ElMaestro,

❝ it is rather experimental.


:-D

❝ […] which means we have:

❝ A variance for T (combined within and between)

❝ A variance for within-R

❝ A variance for between-R


Correct. Will be interesting what you get because \(\sigma_{wT}^2+\sigma_{bT}^2\):
0.04367 (Phoenix) and 0.03771 (SAS).

❝ Hessian, positive definite, etc.. [image]all this comes down to the details of SAS's or WinNonlin's optimiser. I am playing around with optim in R (BFGS, L-BFGS-B bounded, and Nelder-Mead) and with one of my own making.


If you succeed, the community will love you. Might win you the Fields medal.

As long as a genius (you?) is not able to come up with a solution working in all cases, I can only repeat:

Avoid partial replicate designs!

It might not be possible to evaluate the study for ABE (though RSABE works in any case).
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
23,654 posts in 4,992 threads, 1,571 registered users;
155 visitors (0 registered, 155 guests [including 30 identified bots]).
Forum time: 16:20 CEST (Europe/Vienna)

Always listen to experts.
They’ll tell you what can’t be done and why.
Then do it.    Robert A. Heinlein

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5