Braveheart! [🇷 for BE/BA]

posted by Helmut Homepage – Vienna, Austria, 2020-07-11 17:38 (874 d 08:23 ago) – Posting: # 21674
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Hi ElMaestro,

❝ it is rather experimental.


:-D

❝ […] which means we have:

❝ A variance for T (combined within and between)

❝ A variance for within-R

❝ A variance for between-R


Correct. Will be interesting what you get because \(\sigma_{wT}^2+\sigma_{bT}^2\):
0.04367 (Phoenix) and 0.03771 (SAS).

❝ Hessian, positive definite, etc.. [image]all this comes down to the details of SAS's or WinNonlin's optimiser. I am playing around with optim in R (BFGS, L-BFGS-B bounded, and Nelder-Mead) and with one of my own making.


If you succeed, the community will love you. Might win you the Fields medal.

As long as a genius (you?) is not able to come up with a solution working in all cases, I can only repeat:

Avoid partial replicate designs!

It might not be possible to evaluate the study for ABE (though RSABE works in any case).

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
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