Bioequivalence and Bioavailability Forum • Ratio calculation of fully replicate study

Ratio calculation of fully replicate study [RSABE / ABEL]

posted by Helmut – Vienna, Austria, 2020-07-09 12:51 (1556 d 17:37 ago) – Posting: # 21660
Views: 5,005

Hi Mithu,

❝ […] how to calculate ratio of fully replicate study in excel?

❝ I have prepared one excel sheet in which i have put formula to calculate Partial AUC and AUC0-t.

❝ I am getting correct PK for CMax & AUC's in line with SAS out put but when i am calculating Ratio, it is not matching with SAS out put.

Without knowing your SAS code it would be reading tea leaves. Why on earth do you want to use Excel?

❝ Process followed to calculate ratio in excel is as follows:

❝ 1. from two T and two R taking average and then taking ratio of T /R.

❝ 2. Other case, i had also converted average of both T & R in LN and then taken ratio of LN T & LN R.

$$x/y=\exp (\log_{e}x-\log_{e}y)\;\left\{x,y \in \mathbb{R}^{+} \right\}\; {\color{red}{\neq}}\log_{e}x/\log_{e}y$$

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

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