Ratio calculation of fully replicate study [RSABE / ABEL]

posted by Helmut Homepage – Vienna, Austria, 2020-07-09 08:51 (192 d 03:10 ago) – Posting: # 21660
Views: 1,663

Hi Mithu,

» […] how to calculate ratio of fully replicate study in excel?
» I have prepared one excel sheet in which i have put formula to calculate Partial AUC and AUC0-t.
» I am getting correct PK for CMax & AUC's in line with SAS out put but when i am calculating Ratio, it is not matching with SAS out put.

Without knowing your SAS code it would be reading tea leaves. Why on earth do you want to use Excel?

» Process followed to calculate ratio in excel is as follows:
» 1. from two T and two R taking average and then taking ratio of T /R.
» 2. Other case, i had also converted average of both T & R in LN and then taken ratio of LN T & LN R.
$$x/y=\exp (\log_{e}x-\log_{e}y)\;\left\{x,y \in \mathbb{R}^{+} \right\}\; {\color{red}{\neq}}\log_{e}x/\log_{e}y$$

Dif-tor heh smusma 🖖
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Activity
 Admin contact
21,303 posts in 4,441 threads, 1,487 registered users;
online 7 (0 registered, 7 guests [including 5 identified bots]).
Forum time: Sunday 12:02 UTC (Europe/Vienna)

No problem can stand the assault of sustained thinking.    Voltaire

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5