Ratio calculation of fully replicate study [RSABE / ABEL]

posted by Helmut Homepage – Vienna, Austria, 2020-07-09 10:51 (683 d 08:28 ago) – Posting: # 21660
Views: 2,876

Hi Mithu,

» […] how to calculate ratio of fully replicate study in excel?
» I have prepared one excel sheet in which i have put formula to calculate Partial AUC and AUC0-t.
» I am getting correct PK for CMax & AUC's in line with SAS out put but when i am calculating Ratio, it is not matching with SAS out put.

Without knowing your SAS code it would be reading tea leaves. Why on earth do you want to use Excel?

» Process followed to calculate ratio in excel is as follows:
» 1. from two T and two R taking average and then taking ratio of T /R.
» 2. Other case, i had also converted average of both T & R in LN and then taken ratio of LN T & LN R.
$$x/y=\exp (\log_{e}x-\log_{e}y)\;\left\{x,y \in \mathbb{R}^{+} \right\}\; {\color{red}{\neq}}\log_{e}x/\log_{e}y$$

Dif-tor heh smusma 🖖 [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
22,092 posts in 4,630 threads, 1,567 registered users;
online 12 (0 registered, 12 guests [including 10 identified bots]).
Forum time: Monday 19:19 CEST (Europe/Vienna)

There is no adequate defense, except stupidity,
against the impact of a new idea.    Percy Williams Bridgman

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5