Concentration Statistics - BQL substitution [General Statistics]
Hi Martin,
Thanks for the reference.
I'd love to see a work where someone not only debates BLQ's but also where someone tries to discuss what the various options imply for the residual variability and thus confidence interval in BE trials; the same for missing values. I have a feeling it might not be a big deal, but I dare not say at this point what "big deal" is quantitatively.
❝ In statistical language - values <LLOQ are informatively censored and ignoring this fact can lead to biased results.
❝
❝ Of course, adequate handling would require some modeling which seems to be in contradiction to regulatory thinking as NCA is clearly favored in BA/BE studies. However, I would like to bring a recent paper on this topic to your attention: Barnett H, Geys H, Jacobs T, Jaki T (2020). Methods for Non-Compartmental Pharmacokinetic Analysis with Observations below the Limit of Quantification. Statistics in Biopharmaceutical Research, 1-23
Thanks for the reference.
I'd love to see a work where someone not only debates BLQ's but also where someone tries to discuss what the various options imply for the residual variability and thus confidence interval in BE trials; the same for missing values. I have a feeling it might not be a big deal, but I dare not say at this point what "big deal" is quantitatively.
—
Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- Concentration Statistics - BQL substitution SaraCHenriques 2020-07-01 14:37 [General Statistics]
- Concentration Statistics - BQL substitution Helmut 2020-07-01 15:27
- Concentration Statistics - BQL substitution martin 2020-07-02 09:37
- Data imputation Helmut 2020-07-02 11:15
- Concentration Statistics - BQL substitutionElMaestro 2020-07-02 13:48
- Concentration Statistics - BQL substitution martin 2020-07-02 14:52
- Concentration Statistics - BQL substitution Ben 2020-07-07 16:37
- BQL in BE and PK modeling Helmut 2020-07-08 10:23
- Concentration Statistics - BQL substitution ElMaestro 2020-07-08 11:35
- Roger again mittyri 2020-07-08 12:03
- Concentration Statistics - BQL substitution martin 2020-07-02 09:37
- Concentration Statistics - BQL substitution Helmut 2020-07-01 15:27