higher order crossover methodology [General Sta­tis­tics]

posted by sweiner – 2020-06-30 15:10 (201 d 12:59 ago) – Posting: # 21622
Views: 1,807

» I just want to ask, whether you may want to give some more background information on the situation.
» Because I really was not able to think of a scenario, where considering only a part of the population based on the sequences could provide a benefit […]

Dear Steven, thanks for the feedback!
Here the first part of the 5-way crossover analysis (Part A- 3x3 analysis) would be under fasted conditions (Tablet formulation #1 vs. Tablet formulation #2 vs. Capsule formulation), and if BE is shown for either Tablet formulation vs. Capsule formulation, same subjects would complete in a 2x2 fashion under fed conditions (Tablet #1 or #2 [depending on BE result] vs. Capsule). In the final analysis, once all 5 sequences complete all 5 periods, fasted state vs. fed state to be compared for BE.


Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5[Helmut]

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