higher order crossover methodology [General Sta­tis­tics]

posted by sweiner – 2020-06-30 17:10 (83 d 19:37 ago) – Posting: # 21622
Views: 1,608

» I just want to ask, whether you may want to give some more background information on the situation.
» Because I really was not able to think of a scenario, where considering only a part of the population based on the sequences could provide a benefit […]

Dear Steven, thanks for the feedback!
Here the first part of the 5-way crossover analysis (Part A- 3x3 analysis) would be under fasted conditions (Tablet formulation #1 vs. Tablet formulation #2 vs. Capsule formulation), and if BE is shown for either Tablet formulation vs. Capsule formulation, same subjects would complete in a 2x2 fashion under fed conditions (Tablet #1 or #2 [depending on BE result] vs. Capsule). In the final analysis, once all 5 sequences complete all 5 periods, fasted state vs. fed state to be compared for BE.


Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5[Helmut]

Complete thread:

Activity
 Admin contact
21,069 posts in 4,392 threads, 1,467 registered users;
online 26 (1 registered, 25 guests [including 4 identified bots]).
Forum time: Tuesday 12:48 CEST (Europe/Vienna)

Everybody is a Bayesian.
It’s just that some know it, and some don’t.    Trivellore Raghunathan

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5