steady state for modified release [Regulatives / Guidelines]

posted by apapanas  – Greece, 2020-06-24 16:25 (957 d 14:06 ago) – Posting: # 21574
Views: 2,583

Dear Helmut,

Is there a threshold value for linearity indexes (AUC0-tau,ss / AUC0-inf, SD) over which the superposition principle is no longer applicable?

Thank you in advance.

Kindest regards,
Antigoni

Complete thread:

UA Flag
Activity
 Admin contact
22,481 posts in 4,710 threads, 1,603 registered users;
19 visitors (0 registered, 19 guests [including 9 identified bots]).
Forum time: 05:31 CET (Europe/Vienna)

The difference between a surrogate and a true endpoint
is like the difference between a cheque and cash.
You can get the cheque earlier but then,
of course, it might bounce.    Stephen Senn

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5