noncentral normal ratio [NCA / SHAM]

posted by mittyri – Russia, 2020-06-20 23:04 (330 d 00:43 ago) – Posting: # 21553
Views: 2,737

Hi ElMaestro,

» In perspective, history has been somewhat cruel to anyone assume T=R for example in relation to power and sampe sizes. In other words, what is needed (if there is a need at all?!?) is a "Cauchy distribution with the equivalent of a noncentrality parameter", for lack of better wording.

but in the link above you can see
Uncorrelated noncentral normal ratio
...Under certain conditions, a normal approximation is possible...

Correlated noncentral normal ratio
...The offset result is also consistent with the "Cauchy" correlated zero-mean Gaussian ratio distribution in the first section...

Kind regards,

Complete thread:

 Admin contact
21,462 posts in 4,487 threads, 1,514 registered users;
online 6 (0 registered, 6 guests [including 1 identified bots]).
Forum time: Sunday 23:48 CEST (Europe/Vienna)

Pharmacokinetics may be simply defined as
what the body does to the drug,
as opposed to pharmacodynamics, which may be defined as
what the drug does to the body.    Leslie Z. Benet

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz