Bioequivalence and Bioavailability Forum • noncentral normal ratio

noncentral normal ratio [NCA / SHAM]

posted by mittyri – Russia, 2020-06-20 21:04 (126 d 13:30 ago) – Posting: # 21553
Views: 2,093

Hi ElMaestro,

» In perspective, history has been somewhat cruel to anyone assume T=R for example in relation to power and sampe sizes. In other words, what is needed (if there is a need at all?!?) is a "Cauchy distribution with the equivalent of a noncentrality parameter", for lack of better wording.

but in the link above you can see

Uncorrelated noncentral normal ratio

...Under certain conditions, a normal approximation is possible...



Correlated noncentral normal ratio

...The offset result is also consistent with the "Cauchy" correlated zero-mean Gaussian ratio distribution in the first section...

—
Kind regards,
Mittyri

Complete thread:

Fantastic PK parameters and where to find them Astea 2020-06-12 14:22 [NCA / SHAM]
- Fantastic post 👍🏽 Helmut 2020-06-12 16:23
  - Rattleback Astea 2020-06-13 10:17
    - Chatter Helmut 2020-06-13 12:28
      - Reinventing the Hula-Hoop Astea 2020-06-16 01:33
        
        Hula-Hoop references Helmut 2020-06-16 13:07
        
        Prof. Keller vs. Yamaoka mittyri 2020-06-17 14:28
        
        SHAM(e) math Astea 2020-06-23 14:41
        
        SHAM(e) math Helmut 2020-06-23 15:55
        
        OT: Möbius strip Astea 2020-06-23 21:41
        
        OT: Möbius strip Helmut 2020-06-24 11:29
- More stuff Helmut 2020-06-13 15:28
- MRT and Gravity duration mittyri 2020-06-14 22:24
- Fantastic PK parameters and where to find them ElMaestro 2020-06-16 09:46
  - Cauchy distribution mittyri 2020-06-16 10:54
    - Cauchy distribution Helmut 2020-06-16 13:14
    - Cauchy distribution ElMaestro 2020-06-20 10:33
      - noncentral normal ratiomittyri 2020-06-20 23:04