Bioequivalence and Bioavailability Forum

Hi d_labes,

Thanks for your thoughts.
Indeed the study has passed and I would not have posted it if the ratio's had been slightly reduced for both sequences; would have accepted that B affects A to a clinically irrelevant degree.
However, as the ratios are rather different for the two sequences, one of the two being a reduction of 21% and the other being no effect, I felt that this needed some more thought and hoped that some explanation might be found in the data. For one sequence there is a pretty consistent lower ratio, which might have clinical implications, even though the good ratio for the other sequence - and the sample size maybe - makes that the end result passes. I was wondering how to deal with that or if any explanation might/needs to be found to reassure me. The low ratio for one of the two sequences makes me feel a bit uncomfortable.

Regards,
Frieda