old study re analysis [NCA / SHAM]

posted by MiLi – 2008-08-06 12:56 (6108 d 15:15 ago) – Posting: # 2154
Views: 7,434
(edited on 2008-08-06 15:14)

Hello,

I am working on a old bioavailability study.
there is only 7 sample times. The first analysis has been done with incremental troncated AUC.
I have calculated AUCinf but the problem is that 1/3 of Tmax is at the last or the last but one sample time. The data even give some (1/6!!) negative Ke!!! It is not a problem in my program because you can verify it on graph.

My question is : According to the study report, there has been no problem to perform the analysis on this data. But, I wonder about the (poor ?) credit that we can give to the results of this first analysis.

Sorry for my poor english.

--
Edit: Category changed. [Jaime]

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