MRT and Gravity duration [NCA / SHAM]

posted by mittyri – Russia, 2020-06-15 00:24 (1397 d 14:04 ago) – Posting: # 21539
Views: 6,139

Dear Astea,

MRT is a most common PK parameters that compels to look at the AUMC. There existed approaches4 to use MRT instead of T1/2 in order to choose the appropriate washout period.


Just my 2 cents regarding MRT. You cannot estimate it for non-IV ways of administration. For non-IV that parameter is called 'gravity duration', since includes both MIT and MRT. See here for discussion.

Kind regards,
Mittyri

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