## OT: Bias of AUCt, AUCall, pAUC [Regulatives / Guidelines]

Hi again Helmut,

there is no doubt that AUC calculation can be biased. Whether the ln difference or ratio is biased, generally, is another matter and this is where I meant to draw the attention - this is the BE outcome. If one could make a case for saying that this bias affects T more often or to a larger extent than it affects R, generally, then that is where the use of this approach would be not just ugly but even worse also clearly biased.
I am not aware this would or should be the case.

Pass or fail!
ElMaestro