OT: Bias of AUCt, AUCall, pAUC [Regulatives / Guidelines]

posted by ElMaestro  – Denmark, 2020-06-09 06:45 (312 d 17:36 ago) – Posting: # 21514
Views: 6,017

Hi again Helmut,

there is no doubt that AUC calculation can be biased. Whether the ln difference or ratio is biased, generally, is another matter and this is where I meant to draw the attention - this is the BE outcome. If one could make a case for saying that this bias affects T more often or to a larger extent than it affects R, generally, then that is where the use of this approach would be not just ugly but even worse also clearly biased.
I am not aware this would or should be the case.

Pass or fail!

Complete thread:

 Admin contact
21,419 posts in 4,475 threads, 1,511 registered users;
online 11 (0 registered, 11 guests [including 4 identified bots]).
Forum time: Sunday 00:22 UTC (Europe/Vienna)

Nothing fails like success because you do not learn anything from it.
The only thing we ever learn from is failure.
Success only confirms our superstitions.    Kenneth E. Boulding

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz