OT: Bias of AUCt, AUCall, pAUC [Regulatives / Guidelines]

posted by ElMaestro  – Denmark, 2020-06-09 08:45 (416 d 20:52 ago) – Posting: # 21514
Views: 6,790

Hi again Helmut,

there is no doubt that AUC calculation can be biased. Whether the ln difference or ratio is biased, generally, is another matter and this is where I meant to draw the attention - this is the BE outcome. If one could make a case for saying that this bias affects T more often or to a larger extent than it affects R, generally, then that is where the use of this approach would be not just ugly but even worse also clearly biased.
I am not aware this would or should be the case.

Pass or fail!
ElMaestro

Complete thread:

Activity
 Admin contact
21,594 posts in 4,515 threads, 1,532 registered users;
online 4 (0 registered, 4 guests [including 3 identified bots]).
Forum time: Saturday 05:38 CEST (Europe/Vienna)

Restlessness is discontent –
and discontent is the first necessity of progress.
Show me a thoroughly satisfied man 
and I will show you a failure.    Thomas Alva Edison

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5