OT: Bias of AUCt, AUCall, pAUC [Regulatives / Guidelines]

posted by ElMaestro  – Belgium?, 2020-06-09 06:45 (139 d 00:55 ago) – Posting: # 21514
Views: 4,592

Hi again Helmut,

there is no doubt that AUC calculation can be biased. Whether the ln difference or ratio is biased, generally, is another matter and this is where I meant to draw the attention - this is the BE outcome. If one could make a case for saying that this bias affects T more often or to a larger extent than it affects R, generally, then that is where the use of this approach would be not just ugly but even worse also clearly biased.
I am not aware this would or should be the case.

I could be wrong, but...

Best regards,
ElMaestro

No, of course you do not need to audit your CRO if it was inspected in 1968 by the agency of Crabongostan.

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