OT: Bias of AUCt, AUCall, pAUC [Regulatives / Guidelines]

posted by ElMaestro  – Denmark, 2020-06-09 10:45 (2198 d 07:54 ago) – Posting: # 21514
Views: 23,684

Hi again Helmut,

there is no doubt that AUC calculation can be biased. Whether the ln difference or ratio is biased, generally, is another matter and this is where I meant to draw the attention - this is the BE outcome. If one could make a case for saying that this bias affects T more often or to a larger extent than it affects R, generally, then that is where the use of this approach would be not just ugly but even worse also clearly biased.
I am not aware this would or should be the case.

Pass or fail!
ElMaestro

Complete thread:

UA Flag
Activity
 Admin contact
23,654 posts in 4,992 threads, 1,571 registered users;
133 visitors (0 registered, 133 guests [including 13 identified bots]).
Forum time: 18:39 CEST (Europe/Vienna)

Always listen to experts.
They’ll tell you what can’t be done and why.
Then do it.    Robert A. Heinlein

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5