## Dead dogs [Regulatives / Guidelines]

Hi mittyri,

» I had in mind more simplistic approach: shiny app to give points, parameters of 2cpt model and to see what parameters will give ratio less than 80%.

Yep but that’s for a particular study where you have some ideas about the PK model. I had a more general approach in mind.

» » … должно быть ≈ should be or must be?
» » In guidelines commonly “should be” is used. […] Does it smell of a recommendation or rather a requirement?
»
» That's a matter of expert's taste and mood
» see later:
» Однако если AUC(0–t) не перекрывает 80 процентов AUC(0–∞) в более чем 20 процентах случаев, следует усомниться в результатах такого исследования.
» Are you good enough to extinguish doubts from expert's mind? You never know!

следует усомниться ≈ should doubt.
As Nastia wrote:
» We use "следует" to slightly soften the meaning…
But you are right; to dispel doubts can be difficult.

» » The value of the last triangle depends on the time interval between the time point of the last measured concentration and the next one with C=0. You would only get a meaningful result if (1) you use the lin-up/log-down trapezoidal and (2) the interval equals t½. Since (2) is never fulfilled for all profiles, forget it.
»
» Regarding (1): lin-up/log-down is overriden by linear rule if the end point is non-positive.

I should have RTFM. While you replied I deleted this part from my OP, since esp. (2) is nonsense.

Dif-tor heh smusma 🖖
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
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