Dead dogs [Regulatives / Guidelines]

posted by Helmut Homepage – Vienna, Austria, 2020-06-08 12:40 (1389 d 13:00 ago) – Posting: # 21509
Views: 11,793

Hi mittyri,

❝ I had in mind more simplistic approach: shiny app to give points, parameters of 2cpt model and to see what parameters will give ratio less than 80%.


Yep but that’s for a particular study where you have some ideas about the PK model. I had a more general approach in mind.

❝ ❝ … должно быть ≈ should be or must be? :-D

❝ ❝ In guidelines commonly “should be” is used. […] Does it smell of a recommendation or rather a requirement?


❝ That's a matter of expert's taste and mood :cool:

❝ see later:

Однако если AUC(0–t) не перекрывает 80 процентов AUC(0–∞) в более чем 20 процентах случаев, следует усомниться в результатах такого исследования.

❝ Are you good enough to extinguish doubts from expert's mind? You never know!


следует усомниться ≈ should doubt.
As Nastia wrote:

❝ We use "следует" to slightly soften the meaning…

But you are right; to dispel doubts can be difficult.

❝ ❝ The value of the last triangle depends on the time interval between the time point of the last measured concentration and the next one with C=0. You would only get a meaningful result if (1) you use the lin-up/log-down trapezoidal and (2) the interval equals t½. Since (2) is never fulfilled for all profiles, forget it.


❝ Regarding (1): lin-up/log-down is overriden by linear rule if the end point is non-positive.


I should have RTFM. While you replied I deleted this part from my OP, since esp. (2) is nonsense.

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
22,957 posts in 4,819 threads, 1,636 registered users;
62 visitors (0 registered, 62 guests [including 10 identified bots]).
Forum time: 00:40 CET (Europe/Vienna)

Nothing shows a lack of mathematical education more
than an overly precise calculation.    Carl Friedrich Gauß

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5