Dead dogs [Regulatives / Guidelines]

posted by Helmut Homepage – Vienna, Austria, 2020-06-08 12:40 (975 d 22:44 ago) – Posting: # 21509
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Hi mittyri,

❝ I had in mind more simplistic approach: shiny app to give points, parameters of 2cpt model and to see what parameters will give ratio less than 80%.


Yep but that’s for a particular study where you have some ideas about the PK model. I had a more general approach in mind.

❝ ❝ … должно быть ≈ should be or must be? :-D

❝ ❝ In guidelines commonly “should be” is used. […] Does it smell of a recommendation or rather a requirement?


❝ That's a matter of expert's taste and mood :cool:

❝ see later:

Однако если AUC(0–t) не перекрывает 80 процентов AUC(0–∞) в более чем 20 процентах случаев, следует усомниться в результатах такого исследования.

❝ Are you good enough to extinguish doubts from expert's mind? You never know!


следует усомниться ≈ should doubt.
As Nastia wrote:

❝ We use "следует" to slightly soften the meaning…

But you are right; to dispel doubts can be difficult.

❝ ❝ The value of the last triangle depends on the time interval between the time point of the last measured concentration and the next one with C=0. You would only get a meaningful result if (1) you use the lin-up/log-down trapezoidal and (2) the interval equals t½. Since (2) is never fulfilled for all profiles, forget it.


❝ Regarding (1): lin-up/log-down is overriden by linear rule if the end point is non-positive.


I should have RTFM. While you replied I deleted this part from my OP, since esp. (2) is nonsense.

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