Aber meine Dame, das ist alles Unsinn! [Regulatives / Guidelines]
❝ Do you know a legend about Ehrenfest's parrot?
Yes. Do you know Wigner’s friend?
❝ I wish I have that parrot to say: "Aber meine Herren das ist keine Wissenschaft!" every time I get the request to use 80% rule

❝ By the way is not it similar to one used in 1997 by Endrenyi L. et al*?
Yes and no. There are many papers about partial AUCs but most of them deal with early exposure. That’s not what I’m interested in. BTW, a plot of Mei-Ling’s paper1 shows also that the CV decreases with time. OK, little bit unfair. Not with time itself but with median tmax, where pAUC0–ref,tmax.
A small case study2 shows also the high variability of pAUC0–ref,tmax.
❝ As far as I know the war almost starts when russian experts try to translate this word properly. For me "должно быть" sounds like an order.
Shall I say I expected that?
❝ ("Marain was a synthetic language, designed to be phonetically and philosophically as expressive as the pan-human speech apparatus and the pan-human brain would allow")
Great! Do you know Volapük?
❝ I often deal with protocols where the definition of AUC is ambiguously: in the one part of the protocol they are talking about AUC0–72 and in the other - about AUC0–t (AUClast).
Shit. That’s why I give in my protocols even a plot to show how I deal with cut-off times…
❝ About AUC0–t (AUCall) see also Oishi M. et al.
Funny abstract. Can you send me a copy?
- Chen M-L, Davit B, Lionberger R, Wahba Z, Ahn H-Y, Yu LX. Using Partial Area for Evaluation of Bioavailability and Bioequivalence. Parm Res. 2011;28(8):1939–47. doi:10.1007/s11095-011-0421-x.
- Najib NM, Salem I, Hasan R, Idkaidek NM. Effect of Truncated AUC Method on Drug Bioequivalence in Humans. J Bioequiv Bioavail. 2009;1(4):112–4. doi:10.4172/jbb.1000017.
Open access.
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- AUCt not covering at least 80% of AUCinf ratnakar1811 2013-03-05 08:30 [Regulatives / Guidelines]
- AUCt not covering at least 80% of AUCinf d_labes 2013-03-05 11:12
- AUCt not covering at least 80% of AUCinf ratnakar1811 2013-03-06 08:50
- AUCt not covering at least 80% of AUCinf ElMaestro 2013-03-06 11:10
- Science vs. regulations Helmut 2013-03-06 14:30
- Science vs. regulations cakhatri 2013-03-10 08:59
- ratio = difference of logs! Helmut 2013-03-11 01:17
- Science vs. (EMA) GL aka PK primer Helmut 2013-03-11 03:17
- Science vs. regulations qualityassurance 2020-04-23 14:11
- Science vs. regulations Helmut 2020-04-23 17:32
- Science vs. regulations Achievwin 2020-05-07 22:59
- Science vs. regulations Helmut 2020-05-07 23:54
- Science vs. regulations Achievwin 2020-05-07 22:59
- Science vs. regulations Helmut 2020-04-23 17:32
- Science vs. regulations cakhatri 2013-03-10 08:59
- AUCt not covering at least 80% of AUCinf Brus 2018-11-20 13:01
- AUCt not covering at least 80% of AUCinf Astea 2020-06-05 19:05
- So what? Helmut 2020-06-06 12:02
- Carrot and whip Astea 2020-06-06 21:11
- Gedankenexperiment Helmut 2020-06-07 12:41
- Dead dogs mittyri 2020-06-07 20:32
- Aber meine Herren das ist keine physik Astea 2020-06-08 00:08
- Aber meine Dame, das ist alles Unsinn!Helmut 2020-06-08 01:04
- Bizarre paper Helmut 2020-06-08 12:43
- Bizarre paper ElMaestro 2020-06-08 15:33
- OT: Bias of AUCt, AUCall, pAUC Helmut 2020-06-08 15:53
- OT: Bias of AUCt, AUCall, pAUC ElMaestro 2020-06-09 08:45
- OT: Bias of AUCs; example Helmut 2020-06-09 14:07
- OT: Bias of AUCt, AUCall, pAUC ElMaestro 2020-06-09 08:45
- OT: Bias of AUCt, AUCall, pAUC Helmut 2020-06-08 15:53
- Maxwell's demon Astea 2020-06-12 14:15
- Bizarre paper ElMaestro 2020-06-08 15:33
- Dead dogs Helmut 2020-06-08 10:40
- Aber meine Herren das ist keine physik Astea 2020-06-08 00:08
- Dead dogs mittyri 2020-06-07 20:32
- Gedankenexperiment Helmut 2020-06-07 12:41
- Carrot and whip Astea 2020-06-06 21:11
- So what? Helmut 2020-06-06 12:02
- AUCt not covering at least 80% of AUCinf Astea 2020-06-05 19:05
- AUCt not covering at least 80% of AUCinf ratnakar1811 2013-03-06 08:50
- AUCt not covering at least 80% of AUCinf d_labes 2013-03-05 11:12