## Dead dogs [Regulatives / Guidelines]

Hi Helmut,

❝ If you have a lot of time and nothing better to do, perform simulations. On my to-do list for ages. Currently in the “dead dogs” folder of my machine.

I had in mind more simplistic approach: shiny app to give points, parameters of 2cpt model and to see what parameters will give ratio less than 80%.
I like 'dead dogs', will rename it

❝ … должно быть ≈ should be or must be?

❝ In guidelines commonly “should be” is used. What’s your interpretation of the Russian original? Does it smell of a recommendation or rather a requirement?

That's a matter of expert's taste and mood
see later:
Однако если AUC(0–t) не перекрывает 80 процентов AUC(0–∞) в более чем 20 процентах случаев, следует усомниться в результатах такого исследования.
Are you good enough to extinguish doubts from expert's mind? You never know!

❝ Which version of Phoenix are you using?

That rule is not changed for decades in Winnonlin.

❝ The value of the last triangle depends on the time interval between the time point of the last measured concentration and the next one with C=0. You would only get a meaningful result if (1) you use the lin-up/log-down trapezoidal and (2) the interval equals t½. Since (2) is never fulfilled for all profiles, forget it.

Regarding (1): lin-up/log-down is overriden by linear rule if the end point is non-positive.

Kind regards,
Mittyri