Placement of CC [Bioanalytics]

posted by Helmut Homepage – Vienna, Austria, 2020-05-26 13:35 (355 d 07:52 ago) – Posting: # 21473
Views: 5,452

Dear Ohlbe & Shuanghe,

I agree with all of your points.

» The calibration curve is not repeated at the end of the run, so there is no way to check what's happening at the ULOQ, where you may get linearity issues due to detector saturation or ion suppression of the analyte by the IS.

Yep. Many CROs have the CC in duplicates only at the start of the run. IMHO, that should be avoided. I prefer to have one set of singlets at the start and another at the end.

Dif-tor heh smusma 🖖
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Activity
 Admin contact
21,462 posts in 4,487 threads, 1,514 registered users;
online 18 (0 registered, 18 guests [including 15 identified bots]).
Forum time: Sunday 21:28 UTC (Europe/Vienna)

Pharmacokinetics may be simply defined as
what the body does to the drug,
as opposed to pharmacodynamics, which may be defined as
what the drug does to the body.    Leslie Z. Benet

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5