Placement of CC [Bioanalytics]

posted by Helmut Homepage – Vienna, Austria, 2020-05-26 15:35  – Posting: # 21473
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Dear Ohlbe & Shuanghe,

I agree with all of your points.

» The calibration curve is not repeated at the end of the run, so there is no way to check what's happening at the ULOQ, where you may get linearity issues due to detector saturation or ion suppression of the analyte by the IS.

Yep. Many CROs have the CC in duplicates only at the start of the run. IMHO, that should be avoided. I prefer to have one set of singlets at the start and another at the end.

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