Missing samples [Study As­sess­ment]

posted by Amira Gouda – Egypt, 2020-05-02 01:50 (1013 d 09:07 ago) – Posting: # 21383
Views: 3,369

Hi ElMaestro,

thanks for your reply

❝ This guy is clearly not participating PP, his AUC is not outright a meaningful indicator of product performance, so out he goes, I think.


Yes, he actually missed the terminal phase, his AUC0-t is about 17% of his AUC0-inf, also check his figure

[image]

What we could do?

1- Extrapolate to 72 h
2- Use AUC common (0-12)
3- or based on the results of the current study could we make another stage on 12 subjects (knowing that the first one was performed on 24)?
4- Exclude the subject from stat evaluation of AUC(0-t) and include in all other parameters (as long as it does not jeopardize the acceptance of the study)

looking forward to your opinion
thanks

Complete thread:

UA Flag
Activity
 Admin contact
22,488 posts in 4,711 threads, 1,605 registered users;
18 visitors (0 registered, 18 guests [including 4 identified bots]).
Forum time: 09:57 CET (Europe/Vienna)

Many people tend to look at programming styles and languages like religions:
if you belong to one, you cannot belong to others.
But this analogy is another fallacy.    Niklaus Wirth

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5