long acting Injection [Design Issues]

posted by pankajsojitra – India, 2020-04-23 16:40 (1542 d 02:04 ago) – Posting: # 21346
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❝ ❝ But if it is mentioned in monograph that half-life is 17 days following single dose and 46 days after multiple dose, then which half-life we should consider while designing multiple dose study? In the same monograph, it is also stated that steady state is achieved after 4th dose on injection.


❝ Have you found out why the increase in half-life?


Hi J,

Nope, i am not able to find specific reason why half is increased after multiple doses despite the fact that this product doesn't accumulate.

Also it is known that half life following single dose more accurate rather than multiple doses (as there is profiling upto dosing interval only).

Look forward to hear for your comment on this.

Regards
Pankaj

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