long acting Injection [Design Issues]

posted by jag009  – NJ, 2020-04-21 21:06 (590 d 16:00 ago) – Posting: # 21342
Views: 1,081

Hi,

» But if it is mentioned in monograph that half-life is 17 days following single dose and 46 days after multiple dose, then which half-life we should consider while designing multiple dose study? In the same monograph, it is also stated that steady state is achieved after 4th dose on injection.

Have you found out why the increase in half-life?

J

Complete thread:

Activity
 Admin contact
21,785 posts in 4,556 threads, 1,547 registered users;
online 9 (1 registered, 8 guests [including 4 identified bots]).
Forum time: Friday 12:06 CET (Europe/Vienna)

A drug is that substance which, when injected into a rat,
will produce a scientific report.    Anonymous

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5