long acting Injection [Design Issues]

posted by jag009  – NJ, 2020-04-21 21:06 (281 d 17:35 ago) – Posting: # 21342
Views: 770

Hi,

» But if it is mentioned in monograph that half-life is 17 days following single dose and 46 days after multiple dose, then which half-life we should consider while designing multiple dose study? In the same monograph, it is also stated that steady state is achieved after 4th dose on injection.

Have you found out why the increase in half-life?

J

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