Variability EV > IV (always) [PK / PD]

posted by Helmut Homepage – Vienna, Austria, 2020-04-15 00:56 (1017 d 05:15 ago) – Posting: # 21332
Views: 1,437

Hi John,

❝ […] IM injection tends to yield higher variability in PK, is that true? Relative to IV.


By “definition”?
As soon as you add an entry compartment to the system, its inherent variability will increase the overall variability, since the variability you already have (elimination and eventual distribution) will remain constant (driven only by the properties of the drug).

Sorry for the long sentence.

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
22,477 posts in 4,708 threads, 1,603 registered users;
13 visitors (0 registered, 13 guests [including 8 identified bots]).
Forum time: 05:12 CET (Europe/Vienna)

In these matters the only certainty is
that nothing is certain.    Pliny the Elder

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5