Variability EV > IV (always) [PK / PD]

posted by Helmut Homepage – Vienna, Austria, 2020-04-14 22:56 (550 d 09:00 ago) – Posting: # 21332
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Hi John,

» […] IM injection tends to yield higher variability in PK, is that true? Relative to IV.

By “definition”?
As soon as you add an entry compartment to the system, its inherent variability will increase the overall variability, since the variability you already have (elimination and eventual distribution) will remain constant (driven only by the properties of the drug).

Sorry for the long sentence.

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