Variability EV > IV (always) [PK / PD]

posted by Helmut Homepage – Vienna, Austria, 2020-04-14 22:56 (113 d 15:40 ago) – Posting: # 21332
Views: 614

Hi John,

» […] IM injection tends to yield higher variability in PK, is that true? Relative to IV.

By “definition”?
As soon as you add an entry compartment to the system, its inherent variability will increase the overall variability, since the variability you already have (elimination and eventual distribution) will remain constant (driven only by the properties of the drug).

Sorry for the long sentence.

Dif-tor heh smusma 🖖
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Activity
 Admin contact
20,969 posts in 4,374 threads, 1,460 registered users;
online 24 (2 registered, 22 guests [including 13 identified bots]).
Forum time: Thursday 14:37 CEST (Europe/Vienna)

It is a good morning exercise for a research scientist
to discard a pet hypothesis every day before breakfast.
It keeps him young.    Konrad Lorenz

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5