Bioequivalence and Bioavailability Forum

Hello Everyone,

Please help me, i was trying to found information about variability of dextromethorphan, but i only find some chinese articles that i can't download or purchase. I also found an inform from Boehringer Ingelheim "A phase I, single dose, controlled two-way crossover trial to evaluate the relative bioavailability of orally administered dextromethorphan syrup (21 mg dextromethorphan hydrobromide monohydrate) in comparison to dextromethorphan soft pastilles (21 mg dextromethorphan hydrobromide monohydrate) in healthy male and female subjects who are extensive metabolisers for cytochrome P450 (CYP) 2D6" but i think that it's so risky to use the variability from this study.
I forgot to mention that i need to evaluate soft capsules of dextromethorphan, and the sponsor refuses to run a pilot.

thank u for read me.