Dextromethorphan [Study Per­for­mance]

posted by Rosy – Mexico, 2020-03-21 23:38 (308 d 13:32 ago) – Posting: # 21293
Views: 1,480

Hello Everyone,

Please help me, i was trying to found information about variability of dextromethorphan, but i only find some chinese articles that i can't download or purchase. I also found an inform from Boehringer Ingelheim "A phase I, single dose, controlled two-way crossover trial to evaluate the relative bioavailability of orally administered dextromethorphan syrup (21 mg dextromethorphan hydrobromide monohydrate) in comparison to dextromethorphan soft pastilles (21 mg dextromethorphan hydrobromide monohydrate) in healthy male and female subjects who are extensive metabolisers for cytochrome P450 (CYP) 2D6" but i think that it's so risky to use the variability from this study.
I forgot to mention that i need to evaluate soft capsules of dextromethorphan, and the sponsor refuses to run a pilot.

thank u for read me.

Complete thread:

Activity
 Admin contact
21,310 posts in 4,445 threads, 1,489 registered users;
online 6 (0 registered, 6 guests [including 2 identified bots]).
Forum time: Sunday 13:11 CET (Europe/Vienna)

Every man gets a narrower and narrower field of knowledge
in which he must be an expert in order to compete with other people.
The specialist knows more and more about less and less
and finally knows everything about nothing.    Konrad Lorenz

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5