Modelling [Design Issues]

posted by mittyri – Russia, 2020-02-04 09:02 (872 d 03:36 ago) – Posting: # 21140
Views: 2,535

Hi Helmut,

» » B) Capture day 1 PK from time 0 to end of dosing interval, repeat dosing for x # of days (base on dosing interval) to hit SS. On last day of dosing capture time 0 - x (x = whatever hrs needed to fully capture the elimination phase + half-life).
»
» To characterize the PK of a new drug by PK modeling you would always go with this approach and sample as long as possible. Funky things may happen in nonlinear PK (auto-induction / -inhibition, capacity-limited elimination, …)

I don't think the proposed scheme is good enough for modelling such difficult things. There are no Ctau's planned. Moreover, I would mix the A and B for that purpose.

And sorry for a broken link, I cannot carve in my mind that tags for years :-D

Kind regards,
Mittyri

Complete thread:

UA Flag
Activity
 Admin contact
22,165 posts in 4,645 threads, 1,572 registered users;
online 9 (2 registered, 7 guests [including 4 identified bots]).
Forum time: Saturday 13:39 CEST (Europe/Vienna)

Absolute certainty is a privilege of uneducated minds  and fanatics.
It is, for scientific folk, an unattainable ideal.    Cassius J. Keyser

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5