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RegisterA vs B [Design Issues]
Hi John,
citing our Hero:
If one is really interested in λz and has no SD-phase in the study, sampling should continue until concentrations from previous doses are washed out – I would expect any estimate within the MD-profile to be biased towards faster elimination.
why does A take longer time?
Edit: Changed to internal link; see also this post #7. [Helmut]
citing our Hero:
If one is really interested in λz and has no SD-phase in the study, sampling should continue until concentrations from previous doses are washed out – I would expect any estimate within the MD-profile to be biased towards faster elimination.
❝ I have seen both designs but I (and my former bosses) prefer method A. The only drawback I see from A is it takes longer time.
why does A take longer time?
Edit: Changed to internal link; see also this post #7. [Helmut]
—
Kind regards,
Mittyri
Kind regards,
Mittyri
Complete thread:
- Study which captures SD and SS PK Profiles jag009 2020-02-03 20:15 [Design Issues]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- A vs Bmittyri 2020-02-03 21:05
- A vs B jag009 2020-02-03 21:29
- ANDA or NDA? Helmut 2020-02-04 00:57
- Modelling mittyri 2020-02-04 09:02
- Modelling Helmut 2020-02-04 12:17
- Modelling: SD+SS mittyri 2020-02-04 12:38
- Modelling Helmut 2020-02-04 12:17
- Modelling mittyri 2020-02-04 09:02
- A vs Bmittyri 2020-02-03 21:05
Ing. Helmut Schütz