A vs B [Design Issues]

posted by mittyri – Russia, 2020-02-03 21:05 (923 d 10:05 ago) – Posting: # 21136
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Hi John,

citing our Hero:

If one is really interested in λz and has no SD-phase in the study, sampling should continue until concentrations from previous doses are washed out – I would expect any estimate within the MD-profile to be biased towards faster elimination.

» I have seen both designs but I (and my former bosses) prefer method A. The only drawback I see from A is it takes longer time.

why does A take longer time?


Edit: Changed to internal link; see also this post #7[Helmut]

Kind regards,
Mittyri

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