A vs B [Design Issues]
citing our Hero:
If one is really interested in λz and has no SD-phase in the study, sampling should continue until concentrations from previous doses are washed out – I would expect any estimate within the MD-profile to be biased towards faster elimination.
❝ I have seen both designs but I (and my former bosses) prefer method A. The only drawback I see from A is it takes longer time.
why does A take longer time?
Edit: Changed to internal link; see also this post #7. [Helmut]